What is Cardarine GW-501516?
Cardarine is categorised among the selective androgen receptor modulators (SARMs). This is primarily due to its effects as it technically modulates a different receptor. It has been used in bodybuilding circles for decades due to its functionality in shedding unwanted pounds . The effects of this SARM can range from a dramatic increase of lean muscles .
GW-501516 works by connecting with the peroxisome proliferator-activated receptors (PPARs) and increasing gene expressions that are related to energy expenditure. This SARM is very effective for increasing endurance  and improving the body’s ability to heal damages [3, 4, 5]. It could also have a positive impact on reducing ER stress which is linked with the development of heart disease  and type 2 diabetes .
- Chen, W., et al., A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. Scientific Reports, 2015. 5(9884), doi: 10.1038/srep09884.
- Varga, T., et al., PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochimica et Biophysica Acta, 2011. 1812(8): p. 1007-1022.
- Salvado, L., et al., PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism. Diabetologia, 2014. 57(10): p. 2126-35.
- Palomer, X., et al., PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells. International Journal of Cardiology, 2014. 174(1): p. 110-8.
- Guangjie, L., et al., PPARδ Agonist GW501516 Inhibits PDGF-Stimulated Pulmonary Arterial Smooth Muscle Cell Function Related to Pathological Vascular Remodeling. Biomedical Research International, 2013. 903947, doi: 10.1155/2013/903947.
- SARMS World. Cardarine Dosage: Best Cycle Dosages for Men, Women, Fat Loss, CrossFit & Bodybuilding, sarmsworld.com/gw-501516-cardarine/dosage/